Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer

The proviral integration of Moloney virus (PIM) family of protein kinases are overexpressed in many haematological and solid tumours. PIM kinase expression is elevated in PI3K inhibitor-treated breast cancer samples, suggesting a major resistance pathway for PI3K inhibitors in breast cancer, potenti...

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Publicat a:Oncogene
Autors principals: Kennedy, Sean P., O’Neill, Michael, Cunningham, Darren, Morris, Patrick G., Toomey, Sinead, Blanco-Aparicio, Carmen, Martinez, Sonia, Pastor, Joaquin, Eustace, Alex J., Hennessy, Bryan T.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7118022/
https://ncbi.nlm.nih.gov/pubmed/32042115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1202-y
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