Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and BEZ235 in prostate cancer

PIM and PI3K/mTOR pathways are often dysregulated in prostate cancer, and may lead to decreased survival, increased metastasis and invasion. The pathways are heavily interconnected and act on a variety of common effectors that can lead to the development of resistance to drug inhibitors. Most curren...

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Publicado no:Sci Rep
Main Authors: Luszczak, Sabina, Simpson, Benjamin S., Stopka-Farooqui, Urszula, Sathyadevan, Vignesh Krishna, Echeverria, Lina M. Carmona, Kumar, Christopher, Costa, Helena, Haider, Aiman, Freeman, Alex, Jameson, Charles, Ratynska, Marzena, Ben-Salha, Imen, Sridhar, Ashwin, Shaw, Greg, Kelly, John D., Pye, Hayley, Gately, Kathy A., Whitaker, Hayley C., Heavey, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463239/
https://ncbi.nlm.nih.gov/pubmed/32873828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71263-9
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