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Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats
Proteasomal dysfunction is known to be associated with amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD). Our previous reports have shown that a mutant form of ubiquilin-2 (UBQLN2) linked to ALS/FTD leads to neurodegeneration accompanied by accumulations of the proteasome subun...
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| Udgivet i: | Int J Mol Sci |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8122323/ https://ncbi.nlm.nih.gov/pubmed/33919255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22094319 |
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