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Increased Ubqln2 Expression Causes Neuron Death in Transgenic Rats
Pathogenic mutation of ubiquilin 2 (UBQLN2) causes neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. How UBQLN2 mutations cause the diseases is not clear. While overexpression of UBQLN2 with pathogenic mutation causes neuron death in rodent models, deletion of...
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| Publicat a: | J Neurochem |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5117623/ https://ncbi.nlm.nih.gov/pubmed/27456931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13748 |
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