Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments

Defining the principles of T cell migration in structurally and mechanically complex tumor microenvironments is critical to understanding escape from antitumor immunity and optimizing T cell-related therapeutic strategies. Here, we engineered nanotextured elastic platforms to study and enhance T cel...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Tabdanov, Erdem D., Rodríguez-Merced, Nelson J., Cartagena-Rivera, Alexander X., Puram, Vikram V., Callaway, Mackenzie K., Ensminger, Ethan A., Pomeroy, Emily J., Yamamoto, Kenta, Lahr, Walker S., Webber, Beau R., Moriarity, Branden S., Zhovmer, Alexander S., Provenzano, Paolo P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121808/
https://ncbi.nlm.nih.gov/pubmed/33990566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22985-5
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