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pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells
Many lysosome functions are determined by a lumenal pH of ∼5.0, including the activity of resident acid-activated hydrolases. Lysosome pH (pHlys) is often increased in neurodegenerative disorders and predicted to be decreased in cancers, making it a potential target for therapeutics to limit the pro...
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| Veröffentlicht in: | Mol Biol Cell |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Cell Biology
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8120692/ https://ncbi.nlm.nih.gov/pubmed/33237838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-06-0383 |
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