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Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH
Tau, a member of the MAP2/tau family of microtubule-associated proteins, stabilizes and organizes axonal microtubules in healthy neurons. In neurodegenerative tauopathies, tau dissociates from microtubules and forms neurotoxic extracellular aggregates. MAP2/tau family proteins are characterized by t...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6552421/ https://ncbi.nlm.nih.gov/pubmed/30992364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007004 |
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