Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception in Vivo

Pain management devoid of serious opioid adverse effects is still far from reach despite vigorous research and development efforts. Alternatives to classical opioids have been sought after for years and mounting reports of individuals finding pain relief with kratom have recently intensified researc...

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Udgivet i:Biochemistry
Main Authors: Zhou, Yuchen, Ramsey, Steven, Provasi, Davide, El Daibani, Amal, Appourchaux, Kevin, Chakraborty, Soumen, Kapoor, Abhijeet, Che, Tao, Majumdar, Susruta, Filizola, Marta
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119294/
https://ncbi.nlm.nih.gov/pubmed/33274929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00658
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