The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killing

Natural killer (NK) cells are innate immune lymphocytes capable of killing target cells without prior sensitization. One pivotal activating NK receptor is NKG2D, which binds a family of eight ligands, including the major histocompatibility complex (MHC) class I-related chain A (MICA). Human cytomega...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Seidel, Einat, Dassa, Liat, Schuler, Corinna, Oiknine-Djian, Esther, Wolf, Dana G., Le-Trilling, Vu Thuy Khanh, Mandelboim, Ofer
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118558/
https://ncbi.nlm.nih.gov/pubmed/33939764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008807
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