A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain

Stress can induce cell surface expression of MHC-like ligands, including MICA, that activate NK cells. Human cytomegalovirus (HCMV) glycoprotein US9 downregulates the activating immune ligand MICA*008 to avoid NK cell activation, but the underlying mechanism remains unclear. Here, we show that the N...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Seidel, Einat, Dassa, Liat, Kahlon, Shira, Tirosh, Boaz, Halenius, Anne, Seidel Malkinson, Tal, Mandelboim, Ofer
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024260/
https://ncbi.nlm.nih.gov/pubmed/33824318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21983-x
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