Dynamic Co-evolution of Host and Pathogen: HCMV Downregulates the Prevalent Allele MICA*008 to Escape Elimination by NK Cells

Natural killer (NK) cells mediate innate immune responses against hazardous cells and are particularly important for the control of human cytomegalovirus (HCMV). NKG2D is a key NK activating receptor that recognizes a family of stress-induced ligands, including MICA, MICB, and ULBP1-6. Notably, most...

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Udgivet i:Cell Rep
Main Authors: Seidel, Einat, Le, Vu Thuy Khanh, Bar-On, Yotam, Tsukerman, Pinchas, Enk, Jonatan, Yamin, Rachel, Stein, Natan, Schmiedel, Dominik, Djian, Esther Oiknine, Weisblum, Yiska, Tirosh, Boaz, Stastny, Peter, Wolf, Dana G., Hengel, Hartmut, Mandelboim, Ofer
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641326/
https://ncbi.nlm.nih.gov/pubmed/25683719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.029
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