Dynamic Co-evolution of Host and Pathogen: HCMV Downregulates the Prevalent Allele MICA*008 to Escape Elimination by NK Cells

Natural killer (NK) cells mediate innate immune responses against hazardous cells and are particularly important for the control of human cytomegalovirus (HCMV). NKG2D is a key NK activating receptor that recognizes a family of stress-induced ligands, including MICA, MICB, and ULBP1-6. Notably, most...

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Publicado en:Cell Rep
Main Authors: Seidel, Einat, Le, Vu Thuy Khanh, Bar-On, Yotam, Tsukerman, Pinchas, Enk, Jonatan, Yamin, Rachel, Stein, Natan, Schmiedel, Dominik, Djian, Esther Oiknine, Weisblum, Yiska, Tirosh, Boaz, Stastny, Peter, Wolf, Dana G., Hengel, Hartmut, Mandelboim, Ofer
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641326/
https://ncbi.nlm.nih.gov/pubmed/25683719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.029
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