Pseudocell Tracer—A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination

Single cell RNA sequencing (scRNAseq) can be used to infer a temporal ordering of cellular states. Current methods for the inference of cellular trajectories rely on unbiased dimensionality reduction techniques. However, such biologically agnostic ordering can prove difficult for modeling complex de...

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Udgivet i:PLoS Comput Biol
Main Authors: Reiman, Derek, Manakkat Vijay, Godhev Kumar, Xu, Heping, Sonin, Andrew, Chen, Dianyu, Salomonis, Nathan, Singh, Harinder, Khan, Aly A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118552/
https://ncbi.nlm.nih.gov/pubmed/33939691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008094
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