Pseudocell Tracer—A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination

Single cell RNA sequencing (scRNAseq) can be used to infer a temporal ordering of cellular states. Current methods for the inference of cellular trajectories rely on unbiased dimensionality reduction techniques. However, such biologically agnostic ordering can prove difficult for modeling complex de...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Reiman, Derek, Manakkat Vijay, Godhev Kumar, Xu, Heping, Sonin, Andrew, Chen, Dianyu, Salomonis, Nathan, Singh, Harinder, Khan, Aly A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118552/
https://ncbi.nlm.nih.gov/pubmed/33939691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008094
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