A Highly Selective MNK Inhibitor Rescues Deficits Associated with Fragile X Syndrome in Mice

Fragile X syndrome (FXS) is the most common inherited source of intellectual disability in humans. FXS is caused by mutations that trigger epigenetic silencing of the Fmr1 gene. Loss of Fmr1 results in increased activity of the mitogen-activated protein kinase (MAPK) pathway. An important downstream...

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Publicado en:Neurotherapeutics
Autores principales: Shukla, Tarjani, de la Peña, June Bryan, Perish, John M., Ploski, Jonathan E., Stumpf, Craig R., Webster, Kevin R., Thorn, Catherine A., Campbell, Zachary T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer International Publishing 2020
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116363/
https://ncbi.nlm.nih.gov/pubmed/33006091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-020-00932-4
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