A Highly Selective MNK Inhibitor Rescues Deficits Associated with Fragile X Syndrome in Mice

Fragile X syndrome (FXS) is the most common inherited source of intellectual disability in humans. FXS is caused by mutations that trigger epigenetic silencing of the Fmr1 gene. Loss of Fmr1 results in increased activity of the mitogen-activated protein kinase (MAPK) pathway. An important downstream...

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Veröffentlicht in:Neurotherapeutics
Hauptverfasser: Shukla, Tarjani, de la Peña, June Bryan, Perish, John M., Ploski, Jonathan E., Stumpf, Craig R., Webster, Kevin R., Thorn, Catherine A., Campbell, Zachary T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116363/
https://ncbi.nlm.nih.gov/pubmed/33006091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-020-00932-4
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