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Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex
Imidazole glycerol phosphate synthase (HisFH) is a heterodimeric bienzyme complex operating at a central branch point of metabolism. HisFH is responsible for the HisH-catalyzed hydrolysis of glutamine to glutamate and ammonia, which is then used for a cyclase reaction by HisF. The HisFH complex is a...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8115485/ https://ncbi.nlm.nih.gov/pubmed/33980881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22968-6 |
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