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Glutamine Hydrolysis by Imidazole Glycerol Phosphate Synthase Displays Temperature Dependent Allosteric Activation

The enzyme imidazole glycerol phosphate synthase (IGPS) is a model for studies of long-range allosteric regulation in enzymes. Binding of the allosteric effector ligand N'-[5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamide-ribonucleotide (PRFAR) stimulates millisecond (ms) time...

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Bibliografski detalji
Izdano u:Front Mol Biosci
Glavni autori: Lisi, George P., Currier, Allen A., Loria, J. Patrick
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808140/
https://ncbi.nlm.nih.gov/pubmed/29468164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2018.00004
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