The M1/M4 preferring muscarinic agonist xanomeline modulates functional connectivity and NMDAR antagonist-induced changes in the mouse brain

Cholinergic drugs acting at M1/M4 muscarinic receptors hold promise for the treatment of symptoms associated with brain disorders characterized by cognitive impairment, mood disturbances, or psychosis, such as Alzheimer’s disease or schizophrenia. However, the brain-wide functional substrates engage...

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Vydáno v:Neuropsychopharmacology
Hlavní autoři: Montani, Caterina, Canella, Carola, Schwarz, Adam J., Li, Jennifer, Gilmour, Gary, Galbusera, Alberto, Wafford, Keith, Gutierrez-Barragan, Daniel, McCarthy, Andrew, Shaw, David, Knitowski, Karen, McKinzie, David, Gozzi, Alessandro, Felder, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115158/
https://ncbi.nlm.nih.gov/pubmed/33342996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-020-00916-0
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