Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca(2+) ions and L-tryptophan

The human calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor (GPCR) responsible for maintaining Ca(2+) homeostasis in the blood. The general consensus is that extracellular Ca(2+) is the principal agonist of CaSR. Aliphatic and aromatic L-amino acids, such as L-Phe and L-Trp, in...

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Gepubliceerd in:Cell Res
Hoofdauteurs: Ling, Shenglong, Shi, Pan, Liu, Sanling, Meng, Xianyu, Zhou, Yingxin, Sun, Wenjing, Chang, Shenghai, Zhang, Xing, Zhang, Longhua, Shi, Chaowei, Sun, Demeng, Liu, Lei, Tian, Changlin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Singapore 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115157/
https://ncbi.nlm.nih.gov/pubmed/33603117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-021-00474-0
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