Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson’s Disease

Oxidative stress, neuroinflammation and apoptosis are some of the key etiological factors responsible for dopamin(DA)ergic degeneration during Parkinson’s disease (PD), yet the downstream molecular mechanisms underlying neurodegeneration are largely unknown. Recently, a genome-wide association study...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Saminathan, Hariharan, Ghosh, Anamitra, Zhang, Danhui, Song, Chunjuan, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113680/
https://ncbi.nlm.nih.gov/pubmed/33995031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.631375
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