Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity

Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) to the control of EE. Selective antagonism of peripheral Y1R, via the non-brain penetrable antagonist BIBO3304, leads to...

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Vydáno v:Nat Commun
Hlavní autoři: Yan, Chenxu, Zeng, Tianshu, Lee, Kailun, Nobis, Max, Loh, Kim, Gou, Luoning, Xia, Zefeng, Gao, Zhongmin, Bensellam, Mohammed, Hughes, Will, Lau, Jackie, Zhang, Lei, Ip, Chi Kin, Enriquez, Ronaldo, Gao, Hanyu, Wang, Qiao-Ping, Wu, Qi, Haigh, Jody J., Laybutt, D. Ross, Timpson, Paul, Herzog, Herbert, Shi, Yan-Chuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113522/
https://ncbi.nlm.nih.gov/pubmed/33976180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22925-3
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