Inhibition of Y1 receptor signaling improves islet transplant outcome

Failure to secrete sufficient quantities of insulin is a pathological feature of type-1 and type-2 diabetes, and also reduces the success of islet cell transplantation. Here we demonstrate that Y1 receptor signaling inhibits insulin release in β-cells, and show that this can be pharmacologically exp...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Loh, Kim, Shi, Yan-Chuan, Walters, Stacey, Bensellam, Mohammed, Lee, Kailun, Dezaki, Katsuya, Nakata, Masanori, Ip, Chi Kin, Chan, Jeng Yie, Gurzov, Esteban N., Thomas, Helen E., Waibel, Michaela, Cantley, James, Kay, Thomas W., Yada, Toshihiko, Laybutt, D. Ross, Grey, Shane T., Herzog, Herbert
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591241/
https://ncbi.nlm.nih.gov/pubmed/28887564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00624-2
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