Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung adenocarcinoma (ADC) is unknown. In this study, we characterize the immune contexture of invasive lung ADC and its precursors by transcriptomic immune profiling, T cell receptor (TCR) sequencing and multiplex immunofluor...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Dejima, Hitoshi, Hu, Xin, Chen, Runzhe, Zhang, Jiexin, Fujimoto, Junya, Parra, Edwin R., Haymaker, Cara, Hubert, Shawna M., Duose, Dzifa, Solis, Luisa M., Su, Dan, Fukuoka, Junya, Tabata, Kazuhiro, Pham, Hoa H. N., Mcgranahan, Nicholas, Zhang, Baili, Ye, Jie, Ying, Lisha, Little, Latasha, Gumbs, Curtis, Chow, Chi-Wan, Estecio, Marcos Roberto, Godoy, Myrna C. B., Antonoff, Mara B., Sepesi, Boris, Pass, Harvey I., Behrens, Carmen, Zhang, Jianhua, Vaporciyan, Ara A., Heymach, John V., Scheet, Paul, Lee, J. Jack, Wu, Jia, Futreal, P. Andrew, Reuben, Alexandre, Kadara, Humam, Wistuba, Ignacio I., Zhang, Jianjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113327/
https://ncbi.nlm.nih.gov/pubmed/33976164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22890-x
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