Long Term Maturation of Human Cortical Organoids Matches Key Early Postnatal Transitions

Human stem cell-derived models provide the promise of accelerating our understanding of brain disorders. But, not knowing whether they possess the ability to mature beyond late mid-fetal stages potentially limits their utility. So, we leveraged a directed differentiation protocol to comprehensively...

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Pubblicato in:Nat Neurosci
Autori principali: Gordon, Aaron, Yoon, Se-Jin, Tran, Stephen S., Makinson, Christopher D., Park, Jin Young, Andersen, Jimena, Valencia, Alfredo M., Horvath, Steve, Xiao, Xinshu, Huguenard, John R., Pașca, Sergiu P., Geschwind, Daniel H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8109149/
https://ncbi.nlm.nih.gov/pubmed/33619405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-021-00802-y
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