Dissecting impact of regional identity and oncogenic role of human-specific NOTCH2NL in an hESC model of H3.3G34R mutant glioma

H3.3G34R-mutant gliomas are lethal tumors of the cerebral hemispheres, with unknown mechanisms of regional specificity and tumorigenicity. We developed a human embryonic stem cell-based model of H3.3G34R-mutant glioma that recapitulates the key features of the tumors, with cell type-specificity to f...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell Stem Cell
Asıl Yazarlar: Funato, Kosuke, Smith, Ryan C., Saito, Yuhki, Tabar, Viviane
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106629/
https://ncbi.nlm.nih.gov/pubmed/33631117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2021.02.003
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