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Dissecting impact of regional identity and oncogenic role of human-specific NOTCH2NL in an hESC model of H3.3G34R mutant glioma
H3.3G34R-mutant gliomas are lethal tumors of the cerebral hemispheres, with unknown mechanisms of regional specificity and tumorigenicity. We developed a human embryonic stem cell-based model of H3.3G34R-mutant glioma that recapitulates the key features of the tumors, with cell type-specificity to f...
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| Udgivet i: | Cell Stem Cell |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8106629/ https://ncbi.nlm.nih.gov/pubmed/33631117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2021.02.003 |
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