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A Sos proteomimetic as a pan-Ras inhibitor

Aberrant Ras signaling is linked to a wide spectrum of hyperproliferative diseases, and components of the signaling pathway, including Ras, have been the subject of intense and ongoing drug discovery efforts. The cellular activity of Ras is modulated by its association with the guanine nucleotide ex...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Hong, Seong Ho, Yoo, Daniel Y., Conway, Louis, Richards-Corke, Khyle C., Parker, Christopher G., Arora, Paramjit S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106295/
https://ncbi.nlm.nih.gov/pubmed/33926964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2101027118
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