Inhibition of bone morphogenetic protein receptor 2 suppresses pancreatic ductal adenocarcinoma growth by regulating GRB2/PI3K/AKT axis

BACKGROUND: Bone morphogenetic protein receptor 2 (BMPR2) is an important transmembrane serine/threonine kinase that involves oncogenic processes in multiple cancers. However, the role of BMPR2 and its regulatory mechanism in pancreatic ductal adenocarcinoma (PDAC) remain unknown. METHODS: We perfor...

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Veröffentlicht in:Ann Transl Med
Hauptverfasser: Wang, Yazhou, Guo, Huahu, Zhang, Zhengkui, Wang, Qi, Tian, Xiaodong, Yang, Yinmo
Format: Artigo
Sprache:Inglês
Veröffentlicht: AME Publishing Company 2021
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8105856/
https://ncbi.nlm.nih.gov/pubmed/33987255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm-20-2194
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