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De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma

Glioblastoma is a primary brain cancer with a near 100% recurrence rate. Upon recurrence, the tumour is resistant to all conventional therapies, and because of this, 5-year survival is dismal. One of the major drivers of this high recurrence rate is the ability of glioblastoma cells to adapt to comp...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Shireman, Jack M, Atashi, Fatemeh, Lee, Gina, Ali, Eunus S, Saathoff, Miranda R, Park, Cheol H, Savchuk, Sol, Baisiwala, Shivani, Miska, Jason, Lesniak, Maciej S, James, C David, Stupp, Roger, Kumthekar, Priya, Horbinski, Craig M, Ben-Sahra, Issam, Ahmed, Atique U
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8105035/
https://ncbi.nlm.nih.gov/pubmed/33855339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awab020
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