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Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance

Nephrocystin (NPHP1) is a ciliary transition zone protein and its ablation causes nephronophthisis (NPHP) with partially penetrant retinal dystrophy. However, the precise requirements of NPHP1 in photoreceptors are not well understood. Here, we characterize retinal degeneration in a mouse model of N...

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Publicat a:PLoS One
Autors principals: Datta, Poppy, Cribbs, J. Thomas, Seo, Seongjin
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8104407/
https://ncbi.nlm.nih.gov/pubmed/33961633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246358
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