Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet–Biedl syndrome

Compartmentalization and polarized protein trafficking are essential for many cellular functions. The photoreceptor outer segment (OS) is a sensory compartment specialized for phototransduction, and it shares many features with primary cilia. As expected, mutations disrupting protein trafficking to...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Datta, Poppy, Allamargot, Chantal, Hudson, Joseph S., Andersen, Emily K., Bhattarai, Sajag, Drack, Arlene V., Sheffield, Val C., Seo, Seongjin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538681/
https://ncbi.nlm.nih.gov/pubmed/26216965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510111112
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