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The myosin-tail homology domain of centrosomal protein 290 is essential for protein confinement between the inner and outer segments in photoreceptors

Mutations in the centrosomal protein 290 (CEP290) gene cause various ciliopathies involving retinal degeneration. CEP290 proteins localize to the ciliary transition zone and are thought to act as a gatekeeper that controls ciliary protein trafficking. However, precise roles of CEP290 in photorecepto...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Datta, Poppy, Hendrickson, Brandon, Brendalen, Sarah, Ruffcorn, Avri, Seo, Seongjin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916492/
https://ncbi.nlm.nih.gov/pubmed/31694913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009712
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