Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer’s disease

INTRODUCTION: Cerebrovascular pathologies including cerebral amyloid angiopathy (CAA) and blood-brain barrier (BBB) dysregulation are prominent features in the majority of Alzheimer’s disease (AD) cases. METHODS: We performed neuropathologic and biochemical studies on a large, neuropathologically co...

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Publicado en:Alzheimers Dement
Autores principales: Liu, Chia-Chen, Yamazaki, Yu, Heckman, Michael G., Martens, Yuka A., Jia, Lin, Yamazaki, Akari, Diehl, Nancy N., Zhao, Jing, Zhao, Na, DeTure, Michael, Davis, Mary D., Felton, Lindsey M., Qiao, Wenhui, Li, Yonghe, Li, Hongmei, Fu, Yuan, Wang, Na, Wren, Melissa, Aikawa, Tomonori, Holm, Marie-Louise, Oue, Hiroshi, Linares, Cynthia, Allen, Mariet, Carrasquillo, Minerva M., Murray, Melissa E., Petersen, Ronald C., Ertekin-Taner, Nilüfer, Dickson, Dennis W., Kanekiyo, Takahisa, Bu, Guojun
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103951/
https://ncbi.nlm.nih.gov/pubmed/32827351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/alz.12104
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