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Visible-Light-Activated Asymmetric β-C–H Functionalization of Acceptor-Substituted Ketones with 1,2-Dicarbonyl Compounds

We report a visible-light-activated asymmetric β-C(sp(3))–H functionalization of 2-acyl imidazoles and 2-acylpyridines with 1,2-dicarbonyl compounds (typically α-ketoesters) catalyzed by a tailored stereogenic-at-rhodium Lewis acid catalyst. The C–C bond formation products are obtained in high yield...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Ma, Jiajia, Rosales, Anthony R., Huang, Xiaoqiang, Harms, Klaus, Riedel, Radostan, Wiest, Olaf, Meggers, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103785/
https://ncbi.nlm.nih.gov/pubmed/29161036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09152
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