In Chronic Infection, HIV Gag-Specific CD4(+) T Cell Receptor Diversity Is Higher than CD8(+) T Cell Receptor Diversity and Is Associated with Less HIV Quasispecies Diversity

Cellular immune responses to Gag correlate with improved HIV control. The full extent of cellular immune responses comprises both the number of epitopes recognized by CD4(+) and CD8(+) T cells and the diversity of the T cell receptor (TCR) repertoire directed against each epitope. The optimal divers...

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Udgivet i:J Virol
Main Authors: Pilkinton, Mark A., McDonnell, Wyatt J., Barnett, Louise, Chopra, Abha, Gangula, Rama, White, Katie D., Leary, Shay, Currenti, Jennifer, Gaudieri, Silvana, Mallal, Simon A., Kalams, Spyros A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Cellular Response to Infection
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103689/
https://ncbi.nlm.nih.gov/pubmed/33536169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02380-20
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