hERG-deficient human embryonic stem cell-derived cardiomyocytes for modelling QT prolongation

BACKGROUND: Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficiency is still unclear. In this study, we generated an hERG-deficient human car...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Chang, Yun, Li, Ya-nan, Bai, Rui, Wu, Fujian, Ma, Shuhong, Saleem, Amina, Zhang, Siyao, Jiang, Youxu, Dong, Tao, Guo, Tianwei, Hang, Chengwen, Lu, Wen-jing, Jiang, Hongfeng, Lan, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103639/
https://ncbi.nlm.nih.gov/pubmed/33962658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02346-1
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