Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells

PURPOSE: Hexokinase II (HK2) protein expression is elevated in glioblastoma (GBM), and we have shown that HK2 could serve as an effective therapeutic target for GBM. Here, we interrogated compounds that target HK2 effectively and restrict tumor growth in cell lines, patient-derived glioma stem cells...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Agnihotri, Sameer, Mansouri, Sheila, Burrell, Kelly, Li, Mira, Mamatjan, Yasin, Liu, Jeff, Nejad, Romina, Kumar, Sushil, Jalali, Shahrzad, Singh, Sanjay K., Vartanian, Alenoush, Chen, Eric Xueyu, Karimi, Shirin, Singh, Olivia, Bunda, Severa, Mansouri, Alireza, Aldape, Kenneth D., Zadeh, Gelareh
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103287/
https://ncbi.nlm.nih.gov/pubmed/30322879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1854
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