Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells

PURPOSE: Hexokinase II (HK2) protein expression is elevated in glioblastoma (GBM), and we have shown that HK2 could serve as an effective therapeutic target for GBM. Here, we interrogated compounds that target HK2 effectively and restrict tumor growth in cell lines, patient-derived glioma stem cells...

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Dettagli Bibliografici
Pubblicato in:Clin Cancer Res
Autori principali: Agnihotri, Sameer, Mansouri, Sheila, Burrell, Kelly, Li, Mira, Mamatjan, Yasin, Liu, Jeff, Nejad, Romina, Kumar, Sushil, Jalali, Shahrzad, Singh, Sanjay K., Vartanian, Alenoush, Chen, Eric Xueyu, Karimi, Shirin, Singh, Olivia, Bunda, Severa, Mansouri, Alireza, Aldape, Kenneth D., Zadeh, Gelareh
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103287/
https://ncbi.nlm.nih.gov/pubmed/30322879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1854
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