Interplay between IL6 and CRIM1 in thiopurine intolerance due to hematological toxicity in leukemic patients with wild-type NUDT15 and TPMT

NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity. Despite the impact of homozygous CRIM1 on thiopurine toxicity, several patients with wild-type NUDT15, TPMT, and CRIM1 experience thiopurine toxicity, therapeutic failure, and relapse of acute lymp...

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Udgivet i:Sci Rep
Main Authors: Kim, Hyery, You, Seungwon, Park, Yoomi, Choi, Jung Yoon, Ma, Youngeun, Hong, Kyung Tak, Koh, Kyung-Nam, Yun, Sunmin, Lee, Kye Hwa, Shin, Hee Young, Lee, Suehyun, Yoo, Keon Hee, Im, Ho Joon, Kang, Hyoung Jin, Kim, Ju Han
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102572/
https://ncbi.nlm.nih.gov/pubmed/33958640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88963-5
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