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Novel Tetra-Primer ARMS-PCR Assays for Thiopurine Intolerance Susceptibility Mutations NUDT15 c.415C>T and TPMT c.719A>G (TPMT*3C) in East Asians

Thiopurines are clinically useful in the management of diverse immunological and malignant conditions. Nevertheless, these purine analogues can cause lethal myelosuppression, which may be prevented by prospective testing for variants in the thiopurine S-methyltransferase (TPMT) and, in East Asians,...

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Bibliografiske detaljer
Main Authors: Chi-Chun Ho, Wai-Ying Fong, Yuen-Hon Lee, Wing-Tat Poon
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2017-10-01
Serier:Genes
Fag:
Online adgang:https://www.mdpi.com/2073-4425/8/10/285
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