Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT

BACKGROUND: NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity that results in therapeutic failure in pediatric acute lymphoblastic leukemia (ALL). However, many patients with both wild-type (WT) NUDT15 and TPMT still suffer from thiopurine toxicity...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Park, Yoomi, Kim, Hyery, Seo, Heewon, Choi, Jung Yoon, Ma, Youngeun, Yun, Sunmin, Min, Byung-Joo, Seo, Myung-Eui, Yoo, Keon Hee, Kang, Hyoung Jin, Im, Ho Joon, Kim, Ju Han
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328279/
https://ncbi.nlm.nih.gov/pubmed/32611418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02416-7
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