APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia

PURPOSE: Mercaptopurine (MP) is one of the main chemotherapeutics for acute lymphoblastic leukemia (ALL). To improve treatment outcomes, constant MP dose titration is essential to maintain steady drug exposure, while minimizing myelosuppression. We performed two-stage analyses to identify genetic de...

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Publicat a:Cancer Res Treat
Autors principals: Kim, Hyery, Seo, Heewon, Park, Yoomi, Min, Byung-Joo, Seo, Myung-Eui, Park, Kyung Duk, Shin, Hee Young, Kim, Ju Han, Kang, Hyoung Jin
Format: Artigo
Idioma:Inglês
Publicat: Korean Cancer Association 2018
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056975/
https://ncbi.nlm.nih.gov/pubmed/28882023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2017.351
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