Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients

Nudix Hydrolase 15 (NUDT15) and Thiopurine S-Methyltransferase (TPMT) are strong genetic determinants of thiopurine toxicity in pediatric acute lymphoblastic leukemia (ALL) patients. Since patients with NUDT15 or TPMT deficiency suffer severe adverse drug reactions, star (*) allele-based haplotypes...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Park, Yoomi, Kim, Hyery, Choi, Jung Yoon, Yun, Sunmin, Min, Byung-Joo, Seo, Myung-Eui, Im, Ho Joon, Kang, Hyoung Jin, Kim, Ju Han
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580331/
https://ncbi.nlm.nih.gov/pubmed/31244663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00654
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