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CD36-mediated ferroptosis dampens intratumoral CD8(+) T-cell effector function and impairs their antitumor ability
Understanding the mechanisms underlying how T cells become dysfunctional in tumor microenvironment (TME) will greatly benefit cancer immunotherapy. We found that increased CD36 expression in tumor-infiltrating CD8(+) T cells, which was induced by TME-cholesterol, was associated with tumor progressio...
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| Publicado no: | Cell Metab |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8102368/ https://ncbi.nlm.nih.gov/pubmed/33691090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2021.02.015 |
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