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Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of T(H)9 cells programmed by IL-7
Tumor-specific CD4(+) T helper 9 (T(H)9) cells, so-called because of their production of the cytokine interleukin-9 (IL-9), are a powerful effector T cell subset for cancer immunotherapy. We found that pretreatment of naïve CD4(+) T cells with IL-7 further enhanced their differentiation into T(H)9 c...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5961737/ https://ncbi.nlm.nih.gov/pubmed/29018172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aak9741 |
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