CD36-mediated ferroptosis dampens intratumoral CD8(+) T-cell effector function and impairs their antitumor ability

Understanding the mechanisms underlying how T cells become dysfunctional in tumor microenvironment (TME) will greatly benefit cancer immunotherapy. We found that increased CD36 expression in tumor-infiltrating CD8(+) T cells, which was induced by TME-cholesterol, was associated with tumor progressio...

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Bibliographic Details
Published in:Cell Metab
Main Authors: Ma, Xingzhe, Xiao, Liuling, Liu, Lintao, Ye, Lingqun, Su, Pan, Bi, Enguang, Wang, Qiang, Yang, Maojie, Qian, Jianfei, Yi, Qing
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102368/
https://ncbi.nlm.nih.gov/pubmed/33691090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2021.02.015
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