CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma

The prevalence of asthma and airway hyperreactivity (AHR) is increasing at an alarming rate. Group 2 innate lymphoid cells (ILC2s) are copious producers of type 2 cytokines, which leads to AHR and lung inflammation. Here, we show that mouse ILC2s express CD200 receptor (CD200R) and this expression i...

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發表在:Nat Commun
Main Authors: Shafiei-Jahani, Pedram, Helou, Doumet Georges, Hurrell, Benjamin P., Howard, Emily, Quach, Christine, Painter, Jacob D., Galle-Treger, Lauriane, Li, Meng, Loh, Yong-Hwee Eddie, Akbari, Omid
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100131/
https://ncbi.nlm.nih.gov/pubmed/33953190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22832-7
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