Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury

Although much is known about the gene mutations required to drive colorectal cancer (CRC) initiation, the tissue-specific selective microenvironments in which neoplasia arises remains less characterized. Here, we determined whether modulation of intestinal stem cell niche morphogens alone can exert...

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Pubblicato in:Neoplasia
Autori principali: Chen, Tiane, Zeineldin, Maged, Johnson, Blake A., Dong, Yi, Narkar, Akshay, Li, Taibo, Zhu, Jin, Li, Rong, Larman, Tatianna C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2021
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099723/
https://ncbi.nlm.nih.gov/pubmed/33906087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2021.03.010
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