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Rolling-translated EGFR variants sustain EGFR signaling and promote glioblastoma tumorigenicity

BACKGROUND: Aberrant epidermal growth factor receptor (EGFR) activation is observed in over 50% of cases of adult glioblastoma (GBM). Nevertheless, EGFR antibodies are ineffective in clinical GBM treatment, suggesting the existence of redundant EGFR activation mechanisms. Whether circular RNA (circR...

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發表在:Neuro Oncol
Main Authors: Liu, Yi, Li, Zhongjun, Zhang, Maolei, Zhou, Huangkai, Wu, Xujia, Zhong, Jian, Xiao, Feizhe, Huang, Nunu, Yang, Xuesong, Zeng, Rong, Yang, Lixuan, Xia, Zhibo, Zhang, Nu
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099477/
https://ncbi.nlm.nih.gov/pubmed/33325513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa279
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