A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1

BACKGROUND: The RTK/PI3K/AKT pathway plays key roles in the development and progression of many cancers, including GBM. As a regulatory molecule and a potential drug target, the oncogenic role of AKT has been substantially studied. Three isoforms of AKT have been identified, including AKT1, AKT2 and...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Xia, Xin, Li, Xixi, Li, Fanying, Wu, Xujia, Zhang, Maolei, Zhou, Huangkai, Huang, Nunu, Yang, Xuesong, Xiao, Feizhe, Liu, Dawei, Yang, Lixuan, Zhang, Nu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716823/
https://ncbi.nlm.nih.gov/pubmed/31470874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-019-1056-5
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